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Total 49182 results found since Jan 2013.

Clinical profile of acute kidney injury in a pediatric intensive care unit from Southern India: A prospective observational study
Conclusions: Besides the high incidence of AKI in critically ill-children admitted to the PICU (25.1%), the condition was associated with adverse outcomes, including high mortality (46.3%) and need for dialysis (27.8%). Infections dominated the etiological profile. Requirement of mechanical ventilation predicted an adverse outcome in our patient population.
Source: Indian Journal of Critical Care Medicine - September 19, 2013 Category: Intensive Care Authors: Sriram KrishnamurthyParameswaran NarayananSivaprakasam PrabhaNivedita MondalSubramanian MahadevanNiranjan BiswalSadagopan Srinivasan Source Type: research

Measurement of Salivary Cortisol Level for the Diagnosis of Critical Illness–Related Corticosteroid Insufficiency in Children*
Objective: To compare serum total, serum free and salivary cortisol in critically ill children. Design: Prospective observational cohort study. Setting: Tertiary pediatric critical care unit at Ronald McDonald Children’s Hospital at Loyola University Medical Center. Patients: We enrolled 59 patients (4 weeks to 18 years of age) between January 2012 and May 2013. Thirty-four patients were included in the salivary to serum free cortisol correlational analysis. Interventions: Blood and saliva samples were obtained simultaneously within 24 hours of admission between the hours of 6 AM and 12 PM. Salivary cortisol was tested b...
Source: Pediatric Critical Care Medicine - May 1, 2015 Category: Pediatrics Tags: Online Clinical Investigations Source Type: research

Cell-Cycle Arrest Biomarkers: Usefulness for Cardiac Surgery-Related Acute Kidney Injury in Neonates and Infants*
Conclusions: These findings question the usefulness of (TIMP-1) × (IGFBP-7) for the prediction of cardiac surgery-related acute kidney injury in neonates and infants when measured within 3 hours of cardiopulmonary bypass.
Source: Pediatric Critical Care Medicine - June 1, 2020 Category: Pediatrics Tags: Renal Critical Care Source Type: research

Pediatric Sepsis: Challenges and Adjunctive Therapies
Sepsis remains an important challenge in pediatric critical care medicine. This review provides an appraisal of adjunctive therapies for sepsis and highlights opportunities for meeting selected challenges in the field. Future clinical studies should address long-term and functional outcomes as well as acute outcomes. Potential adjunctive therapies such as corticosteroids, hemofiltration, hemoadsorption, and plasmapheresis may have important roles, but still require formal and more rigorous testing by way of clinical trials. Finally, the design of future clinical trials should consider novel approaches for stratifying outco...
Source: Critical Care Clinics - January 4, 2013 Category: Intensive Care Authors: William Hanna, Hector R. Wong Source Type: research

Procalcitonin in the Early Course Post Pediatric Cardiac Surgery
Objective: Procalcitonin has emerged as a promising infection marker, but previous reports from small-sized studies suggest nonspecific elevation of procalcitonin after pediatric heart surgery. As procalcitonin is increasingly used as a marker for infection in the PICU, the aim of this study was to identify factors associated with postoperative procalcitonin elevation and to investigate the role of procalcitonin as an early marker of outcome after cardiac surgery. Design: Prospective observational study. Setting: Single, tertiary referral PICU. Patients: Patients aged 0–16 years following cardiac surgery with or witho...
Source: Pediatric Critical Care Medicine - July 1, 2016 Category: Pediatrics Tags: Cardiac Intensive Care Source Type: research

Early Peritoneal Dialysis and Major Adverse Events After Pediatric Cardiac Surgery: A Propensity Score Analysis*
This study sought to test the effect of early peritoneal dialysis on major adverse events after pediatric cardiac surgery involving cardiopulmonary bypass. Design: In this observational study, the outcomes in infants post cardiac surgery who received early peritoneal dialysis (within 6 hr of completing cardiopulmonary bypass) were compared with those who received late peritoneal dialysis. The primary outcome was a composite of one or more of cardiac arrest, emergency chest reopening, requirement for extracorporeal membrane oxygenation, or death. Secondary outcomes included duration of mechanical ventilation, length of...
Source: Pediatric Critical Care Medicine - February 1, 2019 Category: Pediatrics Tags: Cardiac Intensive Care Source Type: research

Critical Care Response to COVID-19 Pandemic: Building on the Past to Bridge to the Future
At the end of 2021, the COVID-19 pandemic led to more than 286 million cases and over 5.4 million deaths worldwide. COVID-19 is now the deadliest pandemic in the history of the United States. As we reflect on the last 2 years, it is also clear that the pandemic was a pivotal moment for critical care medicine. Never before have the availability and delivery of intensive care medicine been so crucial in a health care crisis. Common critical care issues like acute respiratory distress syndrome (ARDS), ventilators, proning, dialysis, sepsis, and respiratory failure were commonly discussed in the press and social media.
Source: Critical Care Clinics - March 20, 2022 Category: Intensive Care Authors: Michelle Ng Gong, Gregory S. Martin Tags: Preface Source Type: research

Do Intensive Care Unit treatment modalities predict mortality in geriatric patients: An observational study from an Indian Intensive Care Unit
Conclusion: Intensive Care Unit mortality rates increased in the geriatric population requiring mechanical ventilation and inotropes during ICU stay. Only inotropic support could be identified as independent risk factor for mortality.
Source: Indian Journal of Critical Care Medicine - December 5, 2014 Category: Intensive Care Authors: Kanwalpreet SodhiManender Kumar SinglaAnupam ShrivastavaNamita Bansal Source Type: research

Association between heat shock protein 70 gene polymorphisms and clinical outcomes in intensive care unit patients with sepsis
Conclusions: HSP70 genotypes may determine some adverse outcomes in patients with sepsis.
Source: Indian Journal of Critical Care Medicine - April 14, 2014 Category: Intensive Care Authors: Kartik RamakrishnaSrinivasan PugazhendhiJayakanthan KabeerdossJohn Victor Peter Source Type: research

Profile of organ dysfunction and predictors of mortality in severe scrub typhus infection requiring intensive care admission
Conclusions: In this cohort of severe scrub typhus infection with multi-organ dysfunction, survival was good despite high severity of illness scores. APACHE-II score and duration of fever independently predicted mortality.
Source: Indian Journal of Critical Care Medicine - August 5, 2014 Category: Intensive Care Authors: Mathew GriffithJohn Victor PeterGunasekaran KarthikKartik RamakrishnaJohn Antony Jude PrakashRajamanickam C KalkiGeorge M VargheseAnugragh ChrispalKishore PichamuthuRamya IyyaduraiOoriapadickal Cherian Abraham Source Type: research

Pulmonary-renal syndromes: Experience from an Indian Intensive Care Unit
Conclusion: The spectrum of PRS is different in the tropics and tropical syndromes presenting with PRS are not uncommon. Multicentric studies are needed to further characterize the burden, etiology, treatment protocols, and outcomes of PRS in India.
Source: Indian Journal of Critical Care Medicine - June 5, 2015 Category: Intensive Care Authors: Srinivas RajagopalaBaburao Kanthamani Pramod SagarMolly Mary ThabahBH SrinivasRamanathan VenkateswaranSreejith Parameswaran Source Type: research

Impact of dialysis practice patterns on outcomes in acute kidney injury in Intensive Care Unit
Conclusions: Adaption of PIRRT resulted in 37% reduction of utilization of CRRT. The mortality rate was significantly reduced during the period of adaption of PIRRT, possibly due to early initiation of RRT in the latter period for indications such as anuria and metabolic acidosis.
Source: Indian Journal of Critical Care Medicine - January 11, 2016 Category: Intensive Care Authors: Rajeev A AnnigeriVenkatappa NandeeshRamanathan KaruniyaSasikumar RajalakshmiRamesh VenkataramanNagarajan Ramakrishnan Source Type: research

Acute kidney injury-incidence, prognostic factors, and outcome of patients in an Intensive Care Unit in a tertiary center: A prospective observational study
Conclusion: The incidence of AKI was 16.1% in critically ill patients. In patients with AKI, 39.1% patients required HD and 28 days mortality was 49.5%. The study also showed good univariate association of urine output criteria of RIFLE classification to the requirement of HD in AKI patients.
Source: Indian Journal of Critical Care Medicine - June 12, 2016 Category: Intensive Care Authors: Sara KorulaSindhu BalakrishnanShyam SundarVergis PaulAnuroop Balagopal Source Type: research

Clinical profile, intensive care unit course, and outcome of patients admitted in intensive care unit with chikungunya
Conclusions: Patients with chikungunya fever may require ICU admission for organ failure. They are generally elderly patients with underlying comorbidities. Despite aggressive resuscitation and organ support, these patients are at high risk of death. Admission APACHE II score and need for dialysis may predict patients at higher risk of death.
Source: Indian Journal of Critical Care Medicine - January 15, 2018 Category: Intensive Care Authors: Anish Gupta Deven Juneja Omender Singh Suneel Kumar Garg Varun Arora Desh Deepak Source Type: research

Predictors of mortality and length of stay in hospitalized cases of 2009 influenza A (H1N1): Experiences of a tertiary care center
Conclusion: Increased duration of dyspnoea prior to admission, pneumonia, low PaO 2 /FiO 2 ratio at admission and 24 hours later, higher PaCO 2 values on admission, higher O 2 requirement, number of organ failures and use of corticosteroids and delay in specialized treatment were associated with a poorer outcome.
Source: Indian Journal of Critical Care Medicine - October 24, 2013 Category: Intensive Care Authors: Rajesh ChawlaSudha KansalMunish ChauhanAshish JainBipin Narayanrao Jibhkate Source Type: research